Cannabinoid receptors are partly regulated by the mu opioid pathway.
You might want to check some of my previous posts on the subject in
sci.med.cannabis and alt.support.crohns-colitis. In particular, I
theorize that low-dose cannabinoid receptor *antagonists* might be able
to enhance anti-inflammatory cannabinoid signaling by upregulating
cannabinoid receptors similar to the way low-dose naltrexone upregulates
mu opioid receptors. It's on my list of things to try if my helminths,
butyrate and vitamin D3 injections don't achieve the remission for which
On a slightly separate note, given that cathelicidin per se has
anti-allergic effects, I'd bet that cannabinoids are regulators of the
innate immune system.