[Immunology] Re: Endogenous and Exogenous Cannabinoids Modulate Inflammation

[Kofi]

Cannabinoid receptors are partly regulated by the mu opioid pathway.  
You might want to check some of my previous posts on the subject in 
sci.med.cannabis and alt.support.crohns-colitis.  In particular, I 
theorize that low-dose cannabinoid receptor *antagonists* might be able 
to enhance anti-inflammatory cannabinoid signaling by upregulating 
cannabinoid receptors similar to the way low-dose naltrexone upregulates 
mu opioid receptors.  It's on my list of things to try if my helminths, 
butyrate and vitamin D3 injections don't achieve the remission for which 
I'm hoping.

On a slightly separate note, given that cathelicidin per se has 
anti-allergic effects, I'd bet that cannabinoids are regulators of the 
innate immune system.