[Immunology] Monitoring Immune Responses In Disease

biospace from noster-it.com via immuno%40net.bio.net (by biospace from noster-it.com)
Thu Dec 11 01:28:35 EST 2008

A recent study published in Clinical Immunology, the official journal
of the Clinical Immunology Society (CIS), describes a new method
enabling the detection of multiple parameters of single human cells.
The report demonstrates the characterization of specific blood cells
from an individual with type 1 diabetes, providing information about
the role these cells might play in the development of the disease and
during therapy.

Classification of blood cells, including B and T cells, is important
for distinguishing immune responses to pathogens, allergens, or self-
antigens in autoimmune diseases. Although various techniques are
available to identify cell surface determinants, cytokines and
antibodies secreted by blood cells, so far it has not been possible to
study multiple secreted proteins while also assigning surface
displayed markers to individual living cells.

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