sci.med.aids  Re: Where does HIV integrate into genome
sma at wubios.wustl.edu
Tue Jul 28 07:13:20 EST 1998
and when is it activated?
Dear Donald Forsdyke <forsdyke at post.queensu.ca>,
Thank you for your submission to sci.med.aids. Your posting has not
been accepted for posting based on a vote by the moderators, who have
the concerns explained below. If you have important information, we
urge you to spend the time to revise your article and resubmit. Please
consult the sci.med.aids FAQ
(http://www.aids.wustl.edu) for more information.
The vote was:
Yes: No: Marty Howard <martinjh at smartlink.net>-25,"S. Hall"
<shall at compassnet.com>-25
Moderator Marty Howard <martinjh at smartlink.net> voted No for this
Occasionally we make a mistake and reject all copies of a message,
including the original. If this happens to you, please wait a few
days, check to make sure that the message hasn't appeared in
sci.med.aids, and resubmit it.
Please be aware that it can take several days for a post to move
through the moderation process, so be patient.
Moderator "S. Hall" <shall at compassnet.com> voted No for the same reason.
If you think this rejection was inappropriate, or you just want to
talk to a real human, reply to the individual moderators, or to
aids-d, the moderation discussion list for sci.med.aids.
Please include this rejection note, including your original posting,
in your mail. Send aids-d mail to the following address...
aids-d at wubios.wustl.edu
Please do not send a note to us through the sma submission address, or
through the newsgroup. This will require that we process it as a
normal submission and it will not be accepted since we do not approve
postings that contain notes to the moderators
Here is your original article:
From: Donald Forsdyke <forsdyke at post.queensu.ca>
Subject: Re: Where does HIV integrate into genome and when is it
Message-ID: <51881 at sci.med.aids>
References: <51685 at sci.med.aids> <51853 at sci.med.aids>
Date: Mon, 27 Jul 1998 14:13:44 CDT
Organization: Queen's University, Kingston
Axel Boldt wrote:
> 1) Is the HIV provirus always integrated at the same spot in the host
> cell's genome? If yes, where?
> 2) What exactly causes the provirus to become active and produce new
> particles -- is it the activation of the T-cell by antigen?
HIV integrates into AT-rich regions of the cell's genome, which have the
same base composition as itself (AT-rich). Whether this is necessary for
the initial integration, or subsequent survival in the genome, is not
clear. (Base composition is the "accent" of DNA, which may "speak" with
an AT-rich, or a GC-rich accent. Just as someone's accent may sometimes
put you off proposing union with that person, so DNA's accent in a
particular region of the genome may put off HIV integration.)
Most T cells are "latent" in the G-zero stage of the cell cycle. When
the cells are activated by antigen they move into the cell cycle and
proliferate. Under these conditions, just right for HIV replication, the
virus seizes the opportunity and activates, transcribing RNA copies
which are coated to form viral particles.
Sincerely, Donald Forsdyke, Discussion Leader, Bionet.immunology
More information about the Jrnlnote