Use of spermidine- how? why?

Bruce Roe BROE at AARDVARK.UCS.UOKNOR.EDU
Fri Aug 23 08:11:00 EST 1991


According to Lehninger's Biochemistry (certa 1970 edition):
	Spermidine, and other polyamines, will interact with nucleic
acids and neutralize the negative charges. The result is that the
nucleic acids will be more flexible.
	Sorry for this "old" reference, but there is a large body
of literature on the effects of polyamines on nucleic acids.  As
for the effects on proteins, the effect may be similar since many
proteins (especially globular proteins) have a hydrophilic exterior
and thus exposed negative charges most likely may interact with
various polyamines.

The weather today in Oklahoma is predicted to be 93 deg., blue
skys and <30% relative humidity.

Cheers....................bruce
 /\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
 \  Bruce A. Roe                    INTERNET: BROE at aardvark.ucs.uoknor.edu  /
 /  Dept. of Chem. and Biochem.     BITNET:   BROE at uokucsvx                 \
 \  University of Oklahoma          AT&TNET:  405-325-4912 or 405-325-7610  /
 /  620 Parrington Oval, Rm 208     FAXnet:   405-325-6111                  \
 \  Norman, Oklahoma 73019          ICBMnet:  35deg 14min N, 97deg 27min W  \
 \/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/



More information about the Methods mailing list