simulation of DNA melting

WMELCHIOR at NTDOC.NCTNET.GOV WMELCHIOR at NTDOC.NCTNET.GOV
Wed Nov 13 16:50:46 EST 1991


I am interested in calculating the melting, by region, of DNA in the
presence of formamide, as it occurs in denaturing gradient gel electro-
phoresis.  I am interested in obtaining the package of programs described
in Lerman and Silverstein, Meth. Enz. V155, 482-501 (1987) [MELT, MU, and
TRAVEL]; or programs that do similar calculations.

I would appreciate any information regarding:

1)  Sources: eg Lerman's address, cost info, etc.

2)  Comments on experiences doing this type of calculation: hints, positive
and negative experiences.

Thank you.

Bill Melchior
National Center for Toxicological Research
Jefferson, AR  72079
(501) 543-7206

wmelchior at ntdoc.nctnet.gov



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