Dissolving Methotrexate

Bernard A. Kunz kunz at CCU.UMANITOBA.CA
Fri Aug 7 09:17:27 EST 1992

Mike Morris asked how to dissolve methotrexate. Adjust the pH to 12 by adding
concentrated NaOH dropwise. The methotrexate should go into solution as the
pH reaches 12. Then lower the pH to 7 by adding HCl dropwise (concentrated first
and then dilute HCl or you'll overshoot).

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