antisense

[suter at de.dbp.MPG.MPIZ-KOELN.VAX]

dear netters,

something has been puzzling me for some time. 
a lot of people are using anti-sense RNA to inactivate transcripts. Does 
this mean that the endogenous sense transcript is indeed destroyed 
in the target cells ? does it completely disappear ? what is 
the proposed mechanism for breakdown of a double stranded
RNA molecule (are there enzymes that recognize these moieties) ?
 
cheers ! clemens
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Clemens Suter-Crazzolara, PhD
Max-Planck-Institut fuer Zuechtungsforschung
Abteilung Genetische Grundlagen der Zuechtungsforschung
Carl-von-Linne Weg 10
5000 Koeln 30
Tel. xx49-221-5062.221           fax. xx49-221-5062.213
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