epitope size

Carl Saxinger csax at helix.nih.gov
Thu Jun 3 12:05:00 EST 1993

In article <9305310721.AA06035 at cscgpo.anu.edu.au> Klaus.Matthaei at anu.edu.au writes:
>>Dear Immunologists or anyone else for that matter,
>>I have a very quick two part question, that I would be very happy if someone
>>could give me some advice on.
>>What is the average size of a linear epitope that is recognized by a monoclonal
>>Ab, and secondly, is an epitope size of 10 amino acids typically unheard of?
>>Thanks in advance for any suggestions.
>>botdjl at lure.latrobe.edu.au
>Dear Darren
>I do not consider myself as a immunologist but in my darkest memory the
>smallest epitope that seems to raise from my past I thought was about 8
>amino acids but I couldn't give a reference.
>I will also be happy to haer opinions.
>Cheers, Klaus

We have determined one of the antibody epitopes of the HTLV1 envelope
glycoprotein to be three amino acids.  Many others have been found to
be 8 or less.

Cheers, Carl 

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