Proline cis/trans isomerisation

Ben Davis bjd12 at
Wed Oct 27 05:54:35 EST 1993

	I'm working on the NMR structure of a 40 residue peptide that contains
 three prolines. Does anyone know 
	(a) what ratio of cis:trans proline do you expect for a random coil, and
	(b) how far (typically) does the cis:trans isomerisation affect the
chemical shifts observed in other residues
	Thanks a lot,


Ben Davis,
MRC Protein Function and Design,
Cambridge UK

"Even if you do get out its no good, 'cause no matter how far you get,
they'll fetch you back here and bust you 'to pieces. Just ask Clara

The Ballad of Halo Jones

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