Protease inhibitors

[schren13 at uctvax.uct.ac.za]

ANY ADVICE??

I am working on a system in which a membrane-bound protein is solubilized by a
membrane protease.

In order to classify the protease, I treated it with various protease
inhibitors. To my surprise I repeatedly get an increased protease activity when
the serine-protease inhibitor "3,4-dichloroisocoumarin" is used. Is there
anyone out there who has an explanation??

Please send any replies by e-mail to rscholle at physio.uct.ac.za. Thanks a lot.