Altered Sites -Pros? Cons?

[jcuozzo at opal.tufts.edu]

I am about to start a project that will involve making numerous
point mutations in a certain protein, and I have been leaning
towards using Promega's revised Altered Sites protocol.  Is there
anyone out there who has used this kit, successfully or otherwise?
I would really appreciate your insight. Also, if anyone has any
recommendations or warnings about using other double-stranded
site-directed mutagenesis kits, they would also be much appreciated.

Thanks!
J. Cuozzo
jcuozzo at opal.tufts.edu