Ethidium Bromide

[Massimo Delledonne]

In the RED BOOK Bulletin (Current protocol in Molecular Biology)
   supplement 17 - Winter 1992:
 
" .... to our knowledge , ethidium does not easily penetrate living cells and t
hus we think the cancer risk from its topical application to the skin is like t
o be remote. Third, in these experiments (the ability of the compound to revert
 certain his- mutations to his+ in especially engineered strains of Salmonella)
 ethidium produced 200 his+ revertants/microgram, while the smoke from a single
 cigarette produced 18,200 revertants in a related strain that carried the same
mutation. Althoughwe do not wish to push the message too far, we beleive that
this result suggests a clear course of action: one should by all means dispose
of ethidium in a way that inactivates its mutagenic potential; to do so cannot
harm the environmentand may do some small good. At the same time, however, one
 should pity the person whose job it is to empty the ashtrays."  |
 
                                     8-)
 
greetings ...
                                                       Massimo Delledonne
 
 
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