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WHAT IS FIGLU ??????????

Dean R. Appling appling at utbc01.cm.utexas.edu
Wed Jul 6 08:52:25 EST 1994

In article <2v5cek$gid at miasun.med.miami.edu> Michael J McKenzie,
mjmack at umbio.med.miami.edu writes:
>Can anyone tell me what is FIGLU?????
>What is its function?????
>You can e-mail responses to:  mjmack at umbio.med.miami.edu

FIGLU is formiminoglutamate, produced in the catabolism of histidine,
primarily in liver.  The formimino group is typically donated to
tetrahydrofolate, releasing glutamate.  In folate deficiency, however,
FIGLU is excreted in the urine, and can be diagnostic for a folate
deficiency.  See chapter by Shane and Stokstad (pp. 434-455) in Folates
and Pterins, Vol. 1 (Blakley & Benkovic, eds) 1984 Wiley & Sons, NY.

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