Cellular targets for Large T antigen

GWDGV1::KCHOWDH kchowdh at gwdgv1.dnet.gwdg.de
Fri Jun 17 08:13:31 EST 1994


Hi Mike,
You can look up the following paper :
Cellular targets for the large T antigen. D.P.Lane et al. Proc.R.Soc.Lond.
B 226,25-42 (1985). 
Kamal Chowdhury

Can anyone tell me if any good work has been done to explain
the function of SV-40 large T-antigen binding sites in the
genome.  Are they just randomly distributed or does the SV40
protein take advantage of a cellular protein's binding site?
The organism doesn't maintain the site so that SV40 can
transform the cells.  It should have some cellular function, no?

Mike Holloway
mhollowa at epo.som.sunysb.edu



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