Rae Nishi nishir at
Tue Nov 8 19:59:04 EST 1994

Hope you can stand one more comment on this topic.  There are specific
receptors for capasicin on sensory neurons and they appear to be on the
ones that contain substance P and sense slow pain.  Application of
capsaicin causes depolarization of the sensory neuron by opening a
channels in the membrane.  Eating lots of capsaicin destroys the fibers
(probably by an excitotoxic mechanism).  That's why those who eat alot
of chillies are less sensitive to the pain.  In newborn rats injection
of capscaicin causes death of these sensory neurons. 

Rae Nishi
Dept. Cell Biology & Anatomy
Oregon Health Sciences University
Portland Oregon 97201
**that's Orygun, NOT Ora-Gone**

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