Req: Definition of a promoter showing tissue specificity
kchowdh at gwdgv1.dnet.gwdg.de
Wed Nov 23 15:38:10 EST 1994
Viraj writes :
I was wondering if you knew of references which described situations in
which the 'cell culture may not reflect the true in vivo situation'?
What I mean is the following : During embryogenesis and development, many genes are temporally and
spatially regulated in the animal tissue(s) or different cell types. This situation can not be
simulated in cell culture simply because of the lack of many such cell lines or other factors. Here
is one reference that might be helpful.
The cis acting elements known to regulate c-myc expression ex vivo are not sufficient for correct
transcription in vivo. Lavenu et al., Oncogene, 9(2), 527-36. 1994.
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