How to separate plasmid DNA from Chromosome DNA?

Xu, Liang chee1tq at
Tue Nov 29 12:34:00 EST 1994

Is there any good way to separate chromosome DNA from plasmid DNA?
Ony way I kown, is to use ultracentrifuge, since the molecular weights between
plasmid DNA and chromosome DNA are different. But for the large scale
plasmid DNA production up to couple hundred milogram, it is not a very
good and efficent to use ultracentrifuge. Does anybody have good thought?

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