Olomoucine, a cdc2 Protein Kinase inhibitor?

[Bernard Maro]

In article <udbl119.21.000C53FD at bay.cc.kcl.ac.uk>,
udbl119 at bay.cc.kcl.ac.uk (Mandy Johnstone) wrote:

> Hello,
> 
> I am interested in finding out about a cdc2 protein kinase inhibitor that 
> Promega now sell which is called Olomoucine.  In particular how it works and 
> has anyone out there used it or can comment on how good it performed in 
> their hands.  Many thanks in advance.
> 
> Mandy. 
> 
> _______________
> Mandy Johnstone
> (M.Johnstone at bay.cc.kcl.ac.uk)
> 
> King's College, London.

It also inhibits MAP kinase ! In our hands, tested on mouse eggs, it only
worked for a few hours (1-3 ?). It may be inactivated or destroyed, we do
not know yet !

Bernard Maro
Institut Jacques Monod, Paris

-- 
Bernard Maro
Institut Jacques Monod
CNRS - Paris 7