How to calculate PIC?

Craig S. Echt echtc at wis.com
Thu Apr 6 11:34:24 EST 1995


In article <51667.huangbx at mail-g.deakin.EDU.AU>, huangbx at DEAKIN.EDU.AU
("Huang Bixing") wrote:

> Hello netters,
> 
> Here is a quick question. 
> 
> I am encountered by PIC (polymorphism information content), when I read a 
> paper from "Five new microsatellite polymorphisms at the q21 region of 
> human chromosome 21" on the journal" Human Genetics". The auther did not 
> mention how to calculate PIC. So if someone can kindly show me or direct me 
> to certain references?
> 
> Thank you in advance.
> 
> Bixing Huang
> huangbx at deakin.edu.au
> Deakin University of Australia.
  

A formula for PIC is given in Weber (1990) Genomics 7:524-530.  The
original reference may be in Botstein et al. (1980) Amer. J. Hum. Genet
32:314-331.

Craig S. Echt
Research Geneticist
USDA Forest Service Research
Rhinelander, WI



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