Staurosporin-effect on SMC chemotaxis

Saul Needle LNKC60A at
Tue Apr 11 21:27:13 EST 1995

Staurosporin which increases cyclic AMP dependent protein kinase c 
activity in SMC should result in increased migration (collagen membrane-
Boydon chamber)However i have tried 4 orders of magnitude decrease in 
conc (50pM) below literature values and i,m still inhibiting at ~ 95%. 
What's up? Any thoughts would be appreciated.

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