help: crosslinking throug -COOH group

Hun-Sik KIM, M.D. hskim at
Tue Aug 29 01:50:11 EST 1995

Dear Sir:

Does anybody have experiences with crosslinking small molecules
through its carboxyl group to carrier protein? 
I am trying to make hapten with hippuric acid (benzoyl glycine). Since
hippuric acid is a very small molecule, it requires a spacer or
crosslinking molecule which can provide a lenghth more than 6 angstrom
from carriers. 

Any suggestions will be appreicated.

Woong Choi
e-mail: hskim at
fax: (82)-431-272-1603
Dept. of Pharmacol., College of Medicine, Chungbuk Univ.
48 Gaesin-dong, Cheongju, Chungbuk, KOREA

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