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Meeting Announcment:Nuclear Structure-Gene Expression Interrelationships

James Larkin symposia at cambridge.org
Wed Dec 27 16:39:35 EST 1995

Cambridge Symposia, organized to serve the scientific community
through the administration of interdisciplinary conferences in the
biological sciences, is announcing their upcoming meeting, "Nuclear
Structure-Gene Expression Interrelationships" April 30-May 6, 1996 in
Bolton Valley, Vermont.  Deadline for Application/Abstracts is January
10, 1996. and Registration deadline is February 29, 1996.
For more information, including a full program draft, please see our
website: http://www.cambridge.org/symposia/
Cambridge Symposia
1037 Chestnut Street
Newton Upper Falls, MA  02164
tel. (617) 630-1399; fax (617) 630-1395
symposia at cambridge.org
Topic Description:

It is becoming increasingly evident that nuclear structure contributes
to, and in turn is regulated by transcription.  Structural parameters
of the nucleus are functinally linked to control of cell growth,
tissue-specific and developmentally expressed genes.  

The objective of the meeting will be to critically evaluate the
mechanisms by which components of nuclear architecture mediate DNA
replication and genomic imprinting, integration of regulatory
activities at independent promoter elements, responsiveness to
multiple signaling pathways which modulate transcription and RNA
processing, nuclear-cytoplasmic exchange of regulatory factors and
nuclear export of gene transcripts.  Molecular, cellular and
biochemical and genetic approaches will be considered for
experimentally addressing gene regulatory mechanisms associated with
chromatin structure and higher order nuclear organization.
Interrelationships between structural parameters of the nucleus and
control of gene expression will be assessed from the perspectives of:
1) accessibility of promoter elements for interactions with
transcription factors, 2) nuclear domains which support transcription
and/or RNA processing, 3) gene localization, 4) targeting of
transcription factors, and 5) structural constrains on promoter
organization which relate to competency for responsiveness to
transcriptional regulatory signals.  Translation of fundamental
biological regulatory mechanisms operative in cell structure-gene
expression interrelationships to clinical diagnosis and therapeutics
will be explored.

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