Catalase inhibitors ?

[ahillar at your-servername.Lan1.UManitoba.CA]

In article <3eljjb$kh8 at mserv1.dl.ac.uk> <reichhart at astorg.u-strasbg.fr> writes:

>Dear all

>Does anybody know about a catalase inhibitor for whole cells (in tissue
>culture medium) and how to use it.


>        Best Regards,


>                *****  Jean-Marc REICHHART  *****
>                   IBMC   15,rue Reni Descartes
>                    67084-Strasbourg   FRANCE
>              Tel. 88 41 70 34      fax 88 60 69 22
>                  reichhart at astorg.u-strasbg.fr

You can check the specifics yourself, but a paper I've come across mentions 
that they inhibited the catalase activity of cultured rat hepatocytes by 
pretreatment with 20mM aminotriazole without effect on the viability of the 
cells over the subsequent 24hrs. See P.E. Starke and J.L. Farber,  J. Biol. 
Chem.,1985,  260(1):86-92. 

Alex 

Dept. Microbiology
Univ. of Manitoba
ahillar at bldgwall.lan1.umanitoba.ca