intracellular action of terfenadine
kobayasi at MILLES.MED.KYUSHU-U.AC.JP
Sat Jul 15 01:33:04 EST 1995
I would like to know whether terfenadine (TF) could go through the cell
TF is commonly and frequently used for the treatment of allergic disorders.
However, individual case reports showed that TF may cause a fatal or
near-fatal cardiotoxic actions.
Although TF is reported to affect some ion channels, I am thinking of the
possibility of intracellular actions of TF. Would it be possible that TF may
modulate some intracellular signal transduction systems? Any information
would be greatly appreciated. E-mail replies welcome.
Thank you in advance for your help.
Division of Molecular Cardiology
Research Institute of Angiocardiology
Faculty of Medicine, Kyushu University, Japan
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