Kinase recognition site database?
troianovsk_s at MSDISK.WUSTL.EDU
Wed Jun 7 17:24:56 EST 1995
>Does anyone know of a database of consensus sequences for specific protein
>kinases? I'm curious if there is some means of searching a database of all
>substrate proteins for a given protein kinase to determine the amino acid
>sequence recognized by the kinase. e.g. to determine if a consensus site
>can be identified.
>If not a database, does anyone know of a good review article that may
>address this issue for kinases important in signal transduction.
>Any help will be most appreciated.
Here some articles where to start from.
Biochem J 304: 661-662 (1994) 
Consensus sequences for ATP-binding sites in protein kinases do not apply to
diacylglycerol kinases [letter]
D. Schaap, J. van der Wal & W. J. van Blitterswijk
J Biol Chem 269: 29855-29859 (1994) 
Identification of -R-X-(X)-S/T-X3-S/T- as consensus sequence motif for
autophosphorylation-dependent protein kinase.
S. D. Yang, T. J. Huang & T. R. Soderling
Gene 147: 299-300 (1994) 
The primary sequence of murine caveolin reveals a conserved consensus site for
phosphorylation by protein kinase C.
Z. L. Tang, P. E. Scherer & M. P. Lisanti
J Neurochem 62: 1596-603 (1994) 
Protein kinase FA/glycogen synthase kinase-3 predominantly phosphorylates the
in vivo site Thr97-Pro in brain myelin basic protein: evidence for Thr-Pro and
Ser-Arg-X-X-Ser as consensus sequence motifs.
J. S. Yu & S. D. Yang
J Biol Chem 266: 15555-8 (1991) 
Consensus sequences as substrate specificity determinants for protein kinases
and protein phosphatases.
P. J. Kennelly & E. G. Krebs
J Biol Chem 266: 15277-85 (1991) 
Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein
phosphorylation. Characterization of the phosphorylation of c-myc and c-jun
proteins by an epidermal growth factor receptor threonine 669 protein kinase.
E. Alvarez, I. C. Northwood, F. A. Gonzalez, D. A. Latour, A. Seth, C. Abate,
T. Curran & R. J. Davis
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