Glycosylation Signal Sequences?

Gerard Kleijwegt gerard at rigel.bmc.uu.se
Thu Jun 15 11:39:59 EST 1995


In article <3r98v9$oh2 at mail.boku.ac.at>, Iain Wilson <wilson at edv1.boku.ac.at> writes:
|> Yasha at bioch.tamu.edu (Yasha Hartberg) wrote:
|> >
|> > I was wondering if there are known amino acid recognition sequences for
|> > O-linked or N-linked glycosylation.  Any references would be greatly
|> > appreciated.
|> > 
|> > Thanks,
|> > 
|> > Yasha Hartberg
|> > Texas A&M University
|> > "The most beautiful thing in Tokyo is McDonald's."  Andy Warhol
|> 
|> There is the standard N-glycosylation consensus Asn-X-Ser/Thr
|> look at Gavel and von Heijne (1990) Protein Engineering 3:433-442. 
|> However not all Asn-X-Ser/Thr sites get glycosylated even if they are 
|> lumenally/extracellular facing.

where X is not Proline

|> 
|> For O-links there are no obvious rules. See for instance
|> Wilson, Gavel and von Heijne (1991) Biochem. J. 275:529-534
|> 
|> Iain
|> wilson at edv1.boku.ac.at
|> 



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