Killer gene

mpage at mpage at
Mon Mar 13 04:59:53 EST 1995

In article <1995Mar10.103150.1 at>, pekrappu at (Pekka Rappu) writes:
> 	Is there a gene encoding some kind of protein that kills E. coli
>         either indirectly by activating a poison, for example, or
>         directly?
> When the E. coli genome was originally mapped (Kohara et al. (1987), Cell 
50, 495-508), three regions which could not be cloned were identified and 
termed gaps A, B and C. Gap A has been shown to contain the gene lpp, coding 
for an outer membrane lipoprotein, which cannot be cloned as an intact ORF
(Nakamura & Inouye (1979), Cell 18, 1109-1117), presumably due to toxicity 
when overexpressed.

The best source of information on E. coli genes is the E. coli genome project!

Simon Baker
Dudley Page


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