An afterthought, you might be better end-labelling your fragments and
running on a sequencing gel.
The other thing you can try is Nusieve agarose(FMC). It really does
depend on the sizes you want to resolve.
, BKXO at musicb.mcgill.ca wrote:
>I would like to differentiate by gel electrophoresis between DNA
>fragments differing in size by as little as a few base pairs. The size of
>the DNA fragments are between 500-900bp and some differ by as little
>>Can anyone suggest a high resolution mini-gel system that might
>accomplish separation of DNA fragments differing in size by as little
>BKXO at musicb.mcgill.ca>reen