p53 Help

[Eric Hanson]

Hi,

I am new to the world of p53, hence the  potential ignorance in my 
question. I am interested in whether p53 in some way influences the 
expression of my gene of interest (one that is induced by UV DNA 
damage I may add). Are there mouse cell lines (say fibroblasts) in 
which there is a homozygous knockout in p53 that would be good to use 
to stably transfect my gene's promoter/luciferase construct into and 
test for lose of UV induction? Of course I would need the parental 
cells as well. This is just a thought.

Any information would be much appreciated at my email 
Eric.Hansson at medkem.umu.se.

Thanks much.

Eric

Thanks