PCR and Leukaemia

Stephen R. Lasky Stephen_Lasky at brown.edu
Fri Nov 24 08:21:09 EST 1995


In article <494ard$ovt at gnu.mat.uc.pt>, scurado at gemini.ci.uc.pt (Silvia
Curado) wrote:

>         Anyone who, by any chance, is working (or knows someone working) on 
> molecular genetics (PCR) as an approach for the evaluation of minimal
residual 
> disease in leukaemia?...
> 
>         If so, would you kindly send me "the tip"?!
> 
>         Thanks!
>         
>         Silvia. 

This technique is being used to detect residual bcr-abl expressing chronic
myelogeous leukemia cells.  Do a lit search on bcr-abl or CML and pcr and
you'll find the refs.  Here are some places to start if you don't have the
ability to do the lit searches:

Lion, T et al, Leukemia, 9:1353-1360, 1995
Van Rhee, F et al, British Journal of Haematology 90:225-228 1995
Devaraj, P. E et al, British Journal of Haematology 89:349-355, 1995
Cross, Ncp et al, Leukemia, 8:186-189, 1994
Pichert, G et al, Leuk Lymphoma, 10:1-8, 1993

Hope that helps
SRLasky

-- 
Stephen R. Lasky Ph.D.
Section of Experimental Therapeutics
Roger Williams Medical Center
Providence, RI 02908
Phone: 401-456-5672      Fax: 401-456-6569
e:mail: Stephen_Lasky at brown.edu



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