Antisense for gene ablation in mice

mcatania at pathology.medsch.ucla.edu mcatania at pathology.medsch.ucla.edu
Fri Oct 20 17:29:15 EST 1995


Hello

I am wondering if anyone knows if creating a transgenic mouse
expressing an antisense RNA would be feasible in leiu of a transgenic
knockout.  I have searched the literature, but can find no instances
of using this method for in vivo gene function analysis beyond the
embryo stage.  
I appreciate any comments anyone may have.

Sincerely,
       Michael
	      Experimental Pathology grad student




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