Shearing genomic DNA

Michael W. Thompson mthom0 at
Tue Aug 6 16:16:21 EST 1996

     In my experience, merely handling genomic DNA is enough to shear it ;)

You might try either using a sonicator, or even simply pipeting it up and down with a 
small bore pipet tip.  Depends on exactly what you're wanting to do with it...

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