Mathew, Check out MACAW (Multiple Alignment Construction & Analysis Workbench) by Greg Schuler et al. of NCBI. i.e Schuler, GD, Altschul, SF, and Lipman, DJ (1991) Proteins Struct. Funct. Genet. 9, 180-190. It's available via ftp://ncbi.nlm.nih.gov/pub/macaw. I think it's a great program. Good luck! Douglas B. Tully, Ph.D. tully at niehs.nih.gov