What makes gels smile?

Dr E. Buxbaum EB15 at le.ac.uk
Tue Dec 10 08:59:15 EST 1996

brett at BORCIM.WUSTL.EDU (brett) wrote:
>You tried slow?!? Smiling comes from uneven heat distribution within the >gel, the heat being focused in the center of the gel. This lowers the >resistance in the center, and boosts the current. As the nucleic acids >(and dyes) migrate with this current, they move faster in the center of >the gel. The only solution is to redistribute the heat.

Yes, that's the way I heard the story. Which just leaves me wondering:
How come that my gels are always frowning? (And I run them watercooled)

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