sense and antisense strands

Alex Dobrovic adobrovic at
Thu Dec 19 19:25:54 EST 1996

It is a convention to label the DNA strand that has the same sequence as
the RNA (T replacing U, of course) as the sense strand, because it is the
RNA that has the codons that are translated and this makes things easy to
follow when we consider the DNA.

Consideration that transcription works on Watson Crick complementary base
pairing and that the direction of transcription of the new strand is 5' to
3' as the new strand is concerned makes it unambiguous that RNA is
transcribed from the antisense strand.

>> I have some questions about sence strand and antisence strand when DNA is
>> transcribed.
>> Some say that the strand which is transcribed named sence strand,but others
>> say it antisence strand.
>> Which is right?
>There was a long discussion about this some time ago, in fact, there was
>a call for votes trying to get a consensus about this. I dont know which
>was the result though. Why dont you take a look to the archives of this list?

Alexander Dobrovic, Ph. D.
Chief Scientist
Department of Haematology-Oncology
The Queen Elizabeth Hospital
Woodville, SA 5011, Australia

Affiliate Senior Lecturer
Department of Medicine
University of Adelaide

Tel 61-8-8222 6884
Fax 61-8-8222 6046 (note new numbers as of August 1996)

More information about the Methods mailing list