Specific MAPK-K inhibitor

Alan K. Howe alanhowe at merle.acns.nwu.edu
Fri Feb 2 19:16:14 EST 1996


There's an organic compound that was discovered by a group at 
Parke-Davis that specifically inhibits MEK (MAP kinase kinase) 
activity.  It was described in PNAS, sometime in the middle or 
end of '95.  My questions are two fold:

1.) Has anybody used this compound, and if so, what do you think?

2.) How did you get it?  Can you order some from Parke-Davis, or 
did you have to write to the authors of the PNAS paper and wait a 
year for a response?

Any practical information on this compound would be enormously 
appreciated.
-- 
Alan K. Howe
Northwestern University, Chicago, IL.   USA
alanhowe at merle.acns.nwu.edu




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