Ganciclovir and HeLa Cells - help!

michelle malott mmalott at
Wed Feb 7 14:51:20 EST 1996

I am interested in using ganciclovir for negative selection in HeLa 
cells transfected with the viral thymidine kinase gene. However, I'm 
having a hard time finding any information in the literature regarding 
the toxicity of ganciclovir to HeLa cells (these are adherent cells). 
Does anybody know if ganciclovir is at all toxic to regular HeLa's 
and/or how HeLa's behave in the presence of this drug once they are 
expressing the viral TK?  Thanks!!

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