Sense/Antisense nonsense
Richard Moldwin
rmoldwin at midway.uchicago.edu
Fri Jan 5 09:37:29 EST 1996
(Please forgive me if this is a duplicate post; I'm using
the new Netscape beta to reply, and its doing strange
things)
This sense/antisense stuff is making my head spin. When
we first started designing antisense oligos, we had the
same problems of conflicting usages in the literature.
Can't we abandon the sense/coding terminology completely?
How about:
For DNA:
Beta Actin Transcribed Strand
Beta Actin Non-transcribed Strand
(The gene name is important in case the opposite strand is
also transcribed)
For mRNA:
Beta Actin mRNA
cDNA to Beta Actin mRNA
-or-
Beta Actin cDNA oligo
(The latter would be the same as the confusing beta actin
antisense)
I assume that there is a consensus that cDNA means a copy
of DNA complementary to the mRNA.
--Rich
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