Antisense and sensibilities

Ferland Louis H. ferlandl at ERE.UMontreal.CA
Sat Jan 6 03:15:34 EST 1996


On 5 Jan 1996, Robert Horton wrote:

> Date: 5 Jan 1996 18:20:20 GMT
> From: Robert Horton <horton at biosci.cbs.umn.edu>
> To: methods at net.bio.net
> Subject: Re: Antisense and sensibilities
> 
> About a dozen posts back somebody wrote the diabolical question:
> 
> : What would you name these?
> : 1. The DNA strand that codes for the ANTISENSE RNA.
> the top strand.
> 
> : 2. The DNA strand that codes for the normal (SENSE RNA)
> the bottom strand
> 
> : 3.  The complementary strand of #1
> the bottom strand
> 
> : 4.  The complementary strand of #2 
> the top strand
> 
> Hey, simple terms with no historical complexities. Even us simple
> molecular biologists can usually figure which strand is up for simple
> coding regions. Also, for more complicated sequences (like a plasmid,
> or a viral genome) there is (or should be) a convention as to which way
> the thing is written. So these terms might even be less confusing than
> "sense", etc., when used for sequences containing reading frames in
> both directions.

FERLAND
...the added complexity of which rules out "top and bottom", doesn't it?

> 
> 
> Robert M. Horton (PhD!)           CAUTION:.sig under construction
> U of M Dermatology Dept          (612)625-8941 http://134.84.47.3
> Box 98 UMHC, 4-154 PWB               horton at biosci.cbs.umn.edu
> Minneapolis, MN 55455                   Disclaimer:"Bob who?"
> 
> 

Dr. Louis H. Ferland
Centre de Recherche, Hotel-Dieu de Montreal
Dept de Nutrition, Universite de Montreal
Phone: (514) 843-2757     FAX: (514) 843-2719




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