monovalent streptavidin

Digs pd1 at
Wed Jan 10 12:52:15 EST 1996

R Hanemaaijer wrote:
> Hi netters,
> Avidin or streptavidin have a high affinity for biotin. A mature
> (strept)avidin molecule is multivalent, since it has four biotin
> binding sites.
> We are looking for monovalent streptavidin. Does anybody know if
> there's a company that sells such a molecule. A second question
> is: Does anybody know if mono- or multivalent streptavidin can be
> or has been produced in prokaryotic or eukaryotic expression systems?

Promega sell "SoftLink" resin which contains monomeric avidin 
coupled to a methacrylate support. Their catalogue gives more 
details, but I'm not aware that they sell the uncoupled protein.

Paul Digard
Division of Virology
Department of Pathology
University of Cambridge

More information about the Methods mailing list