Antisense and sensibilities

Stephen R. Lasky Stephen_Lasky at brown.edu
Thu Jan 11 08:44:24 EST 1996


In article <4d11p1$41v at epx.cis.umn.edu>, horton at biosci.cbs.umn.edu (Robert
Horton) wrote:

> Stephen R. Lasky (Stephen_Lasky at brown.edu) wrote:
> 
> : Why not define the strands based on the action that is taken on them:  the
> : transcribed strand (T-Strand) (for the anti-parallel complementary strand
> : to the mRNA), and the non-transcirbed stand (N-Strand) for the strand with
> : the same sequence as the mRNA? The name of the gene that is transcribed
> : can be added if it has not already been defined (as suggested by Dr.
> : Moldwin).   mRNA should be mRNA or sense-RNA, and anti-Sense RNA should be
> : the anti-parallel complement to the message.  I don't see any ambiguity in
> : this system.
> 
> (Bob emerges from phone booth wearing Devil's Advocate costume):
> Except that "T" and "N" are both used to denote nucleotides!
> 

Bob:  Hadn't really thought of that, but if you use T-strand and N-strand,
you shouldn't get them confused with  NTP or TTP (or any other
nucleoside).  ???

SRLasky

-- 
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Stephen R. Lasky Ph.D.   Brown U/Roger Williams Medical Center,  Providence, RI.   
Phone: 401-456-5672     Fax: 401-456-6569     e:mail: Stephen_Lasky at brown.edu
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America may be unique in being a country which has leapt from barbarism to decadence without touching civilization.  John O'Hara.
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