Does Ultrasound destroy dsDNA?

john brennand john.brennand at
Wed Jan 17 06:24:58 EST 1996


It will leave the DNA "intact" but it will be very, very, sheared.  
Average size around a few hundred bp.

Sonication is the standard way of preparing DNA like this as a blocking 
agent for blots or for reducing the viscocity of E Coli extracts during 
protein purification.


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