rmoldwin at midway.uchicago.edu
Mon Jun 3 07:07:47 EST 1996
Johan Burger wrote:
> Can someone please help:
> The neomycin-phospho-transferase (NPT II) gene confers resistance to Kanamycin
> and Neomycin. Does it also confers resistance to Vancomycin?? If not,
> which gene does?
> Johan Burger
Neomycin, Kanamycin, and G418 are all aminoglycoside
antibiotics. The Neo(R) gene confers resistance to the
whole class. Vancomycin is a complex glycopeptide
antibiotic unrelated to the aminoglycosides. Since those
of us who worry about antibiotic resistance view Vanco as
the last line we have against a growing list of pathogenic
organisms, I would suggest that you avoid using any kind
of Vanco-resistance selection system. A discussion with a
clinical microbiologist or Infectious disease specialist
might be useful.
Why do you want to use Vanco anyway?
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