actinomycin D

William Sun william at
Mon Mar 11 15:39:54 EST 1996

Hello all,

I wish to use actinomycin D to inhibit transcription in brain cells in vivo.
Does anyone know what is the maximum concentration that can be used without
killing the cell.  Also, how long does it take before the drug enters the 
cells and inhibit transcription?   Is there another drug that is more
potent at inhibiting RNA synthesis than act. D?  Any information would be
appreciated.  Thanks.


William Sun, Ph.D.                     Phone: (213)740-3406
University of Southern California      FAX:   (213)740-5687
Los Angeles, CA 90089-2520   

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