Fusion protein activity

[Ron Tate]

KHUANG at CHEMVX.TAMU.EDU wrote:
> 
> Hi, Netters,
> I am very glad to know your experience about the activity of fusion protein
> such GTS-fusion, Thioredoxin-fusion, Mal-fusion. Are fusion protein usually
> active?
> 
> Thanks
> 
> Huanfg


It really depends on the structure of individual proteins, if the tail
is involved in active site then maybe not or if the tail has to be
buried in the core of the enzyme then probably not if however it is
positioned along the outside of the enzyme and does not have to be
mobile it well may be active as a fusion.  I know this isn't much help
but I don't think you can generalize whether most fusions are active or
not.
-- 
>>>>>>--------------------------->
Ron
Tate                                                                   
Lab of Franklin Leach
Dept. of Biochem. & Molecular Biology
Oklahoma State University 
rtate at bmb-fs1.biochem.okstate.edu
(405) 744-9326
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