Do HIS-TAGs bind to nucleic acids?

A. Walsh GENAPW at
Wed Oct 16 11:18:16 EST 1996

I have heard rumours of HIS-TAGed proteins giving unusual footprints on 

Does anyone know if these rumours are true, or if there is any other 
evidence that the HIS TAG can interact directly with DNA or RNA?

Andy Walsh

genapw at

Department of Biology
University of Leeds

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