"CNS specific knock-outs for cre-lox"

z un691cs at genius.embnet.dkfz-heidelberg.de
Mon Sep 23 06:31:45 EST 1996


here in the lab we would like to make CNS specific knock-outs
with the cre-lox system. For this, I am looking for a CNS (not
PNS !) specific promoter, which is either expressed only in CNS
neurons, or in CNS neurons as well as glia. neurofilament, 14-3-3,
vimentin, nestin or negrin won't do, as these are either 
expressed in PNS neurons or outside by non-neural cells as well.

Clemens Suter-Crazzolara, PhD

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