constrained random peptide libraries

[Scott Vande Pol]

We plan to do some fishing into a random peptide library and would like to
know the experience of those that have used constrained peptides  vs
unconstrained peptides.  Are peptides that are removed from their
constrained vectors likely to still function in an unconstrained context? 
ie is the greater likelyhood of getting a "hit" on the constrained library
offset by the potential lack of function when the peptides are subsequently
used unconstrained?

-- 
Scott Vande Pol
Case Western Reserve University
Department of Pathology
Cleveland Oh. 44106
sbv at pop.cwru.edu