DNA Hairpins

[Mary_Ann_Brow at twt.com]

Check out the following references for 3 and 4 nt loops that confer
remarkable stability to short stems.
DNA tetraloop [Antao et al. (1991) Nucl. Acids Res. 19:5901]
DNA triloop [Hiraro et al. (1994) Nuc. Acids Res. 22:576]

Mary Ann Brow
Third Wave Technologies, Inc.

In article <6616tq$ii2$1 at usenet.bham.ac.uk>,
"Tom Burr" <t.burr at bham.ac.uk> wrote:
>I would like to design a DNA oligonucleotide, which will form a stable
>hairpin loop for use in protein binding. I am having trouble finding
>references regarding the number of bases within the loop and how this
>affects stability.
>Any suggestions would be greatly appreciated.
>
>