Mechanism of EMS Action?
leach at bu.edu
Thu Feb 13 14:54:16 EST 1997
Namjin Chung (nc1 at acpub.duke.edu) wrote:
: Hi, all!
: EMS (MMS) is an alkylating agent, and widely used in mutagenesis. I
: wonder how this mutagen work on DNA: probably by modifying bases so that
: mismatches would happen? Is there any other molecules, proteins or lipids,
: being alkylated by EMS? If there is, how does EMS affect their biological
MMS (methyl-methane sulfonate)
is mutagenic by the following way:
causes alkaylation of guanosine at the 7 position with resulting tautomeric
: Any comments would be greatly appreciated. TIA.
: Namjin Chung, who knows little and asks a lot!
: Program in Molecular Cancer Biology
: Duke University Medical Center
: Durham, North Carolina
..... Martin Leach Email:leach at bu.edu
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